CD74 knockout protects against LPS-induced myocardial contractile dysfunction through AMPK-Skp2-SUV39H1-mediated demethylation of BCLB.

Yuanfei LuoCongcong FanMingjie YangMaolong DongRichard BucalaZhaohui PeiYingmei ZhangJun Ren

Published in: British journal of pharmacology (2020)

Our data suggested that CD74 ablation protected against LPS-induced cardiac anomalies, O2 - production, inflammation and apoptosis through suppression of autophagy in a Skp2-SUV39H1-mediated mechanism.

Keyphrases

lps induced
oxidative stress
inflammatory response
endoplasmic reticulum stress
skeletal muscle
cell death
left ventricular
electronic health record
signaling pathway
nk cells
big data
machine learning
heart failure
radiofrequency ablation
deep learning