Butyrate rather than LPS subverts gingival epithelial homeostasis by downregulation of intercellular junctions and triggering pyroptosis.

Juan LiuYixiang WangHuanxing MengJingting YuHongye LuWenjing LiRuifang LuYibing ZhaoQiqiang LiLi Su

Published in: Journal of clinical periodontology (2019)

Our new findings indicate that butyrate is a potent destructive factor of gingival epithelial barrier and pro-inflammatory mediator, which shed a new light on our understanding of periodontitis initiation.

Keyphrases

anti inflammatory
inflammatory response
single molecule
signaling pathway
nlrp inflammasome
cell adhesion