Extensive perineal ecthyma gangrenosum in leukocyte adhesion deficiency type 1 associated with Staphylococcus hominis bacteremia.
Balamurugan KalyanaprabhakaranVenkataraman Ranjith KumarJaikumar Govindaswamy RamamoorthyPediredla KarunakarDhandapany GunasekaranBibekanand JindalPublished in: Pediatric dermatology (2023)
Leukocyte adhesion deficiency (LAD), a disorder of neutrophil function, is characterized by a defect in leukocyte adhesion to the endothelium. Recurrent infections in the skin, soft tissue, gingiva, and lungs due to Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella sp. are common in these patients. Ecthyma gangrenosum (EG) is an ulcer of skin and subcutaneous tissue with a black eschar and surrounding erythematous halo secondary to a bacterial infection. Here, we report an unusual presentation of LAD type-1 with extensive EG of perineum secondary to Staphylococcus hominis bacteremia treated successfully with combination of granulocyte transfusion and diversion colostomy.
Keyphrases
- biofilm formation
- staphylococcus aureus
- pseudomonas aeruginosa
- soft tissue
- peripheral blood
- candida albicans
- newly diagnosed
- end stage renal disease
- escherichia coli
- cystic fibrosis
- ejection fraction
- chronic kidney disease
- nitric oxide
- wound healing
- peritoneal dialysis
- cardiac surgery
- cell migration
- patient reported outcomes
- drug resistant
- sickle cell disease
- smoking cessation