Changes in mucociliary clearance over time in children with cystic fibrosis.
Beth L LaubeKathryn A CarsonChristopher M EvansVanessa L RichardsonGail SharplessPamela L ZeitlinPeter J MogayzelPublished in: Pediatric pulmonology (2020)
Mucociliary clearance declines significantly over time in children with CF. The decline is associated with PA infection rate and is affected by mucus composition. Children with early slowing of MCC appear to be at risk for developing ventilation inhomogeneity and parenchymal lung damage when they are older.