Acute sleep loss decreases CSF-to-blood clearance of Alzheimer's disease biomarkers.

Haiyan LiuNicolas R BarthélemyVitaliy OvodJames G BollingerYingxin HeSamir L ChahinBrendan AndroffRandall J BatemanBrendan P Lucey

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

These findings show that sleep loss alters some plasma AD biomarkers by lowering brain clearance mechanisms and needs to be taken into account when interpreting individual plasma AD biomarkers but not ratios.

Keyphrases

physical activity
sleep quality
liver failure
cognitive decline
resting state
multiple sclerosis
drug induced
cerebrospinal fluid
functional connectivity
cerebral ischemia