A Yes-Associated Protein (YAP) and Insulin-Like Growth Factor 1 Receptor (IGF-1R) Signaling Loop Is Involved in Sorafenib Resistance in Hepatocellular Carcinoma.

Mai-Huong T NgoSue-Wei PengYung-Che Kuo Chung-Yen Lin Ming-Heng WuChia-Hsien ChuangCheng-Xiang Kao Han-Yin Jeng Gee-Way LinThai-Yen LingTe-Sheng Chang Yen-Hua Huang

Published in: Cancers (2021)

A YAP-IGF-1R signaling loop may play a role in HCC sorafenib resistance and could provide novel potential targets for combination therapy with sorafenib to overcome drug resistance in HCC.

Keyphrases

combination therapy
growth hormone
binding protein
transcription factor
pi k akt
signaling pathway