Comprehensive analysis of 5-hydroxymethylcytosine in zw10 kinetochore protein as a promising biomarker for screening and diagnosis of early colorectal cancer.

Yanqi DangDan HuJingjuan XuChunlin LiYingjue TangZhenhua YangYang LiuWenjun ZhouLi ZhangHanchen XuYangxian XuGuang Ji

Published in: Clinical and translational medicine (2020)

The ZW10 5hmC level may serve as an effective epigenetic biomarker for minimally invasive screening and diagnosis of CRC, and it has higher diagnostic performance in early stages of CRC than it does in advanced stages. In addition, ZW10 could regulate CRC progression through the AKT-mTOR signaling.

Keyphrases

minimally invasive
cell proliferation
dna methylation
gene expression
signaling pathway
protein protein