Aspergillus Utilizes Extracellular Heme as an Iron Source During Invasive Pneumonia, Driving Infection Severity.

Kathryn MichelsAngelica L SolomonYogesh ScindiaLuis Sordo VieiraYana GoddardSpencer WhittenSophie VaulontMarie D BurdickCarl AtkinsonReinhard LaubenbacherBorna Mehrad

Published in: The Journal of infectious diseases (2022)

Invasive aspergillosis induces local hemolysis in infected tissues, thereby supplying heme iron to the fungus, leading to lethal infection.

Keyphrases

gene expression
iron deficiency
red blood cell
acute respiratory distress syndrome