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Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy.

Bingying WangHaoyuan JiaBin ZhangJuanjuan WangCheng JiXueming ZhuYongmin YanLei YinJing YuWenrong XuWenrong Xu
Published in: Stem cell research & therapy (2017)
Our findings indicate that the activation of autophagy induced by hucMSC-Ex can effectively relieve the nephrotoxicity of cisplatin. Therefore, pre-treatment of hucMSC-Ex may be a new method to improve the therapeutic effect of cisplatin.
Keyphrases
  • signaling pathway
  • cell death
  • endoplasmic reticulum stress
  • oxidative stress
  • mesenchymal stem cells
  • drug induced
  • stem cells
  • mouse model
  • combination therapy
  • replacement therapy