[New Potential Therapies for Chronic Hepatitis B].

Published in: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi (2020)

A HBV infection is a dynamic disease and long-term liver inflammation contributes to the development of liver cirrhosis and hepatocellular carcinoma. Currently available nucleos(t)ide analogues and pegylated interferon are effective in inhibiting HBV replication but rarely achieve HBsAg clearance. The present article introduces a new definition of HBV cure and several emerging therapies for HBV cure, including direct acting antivirals and immune modulatory antivirals.

Keyphrases

hepatitis b virus
liver failure
oxidative stress
signaling pathway
molecular docking
risk assessment
molecular dynamics simulations