27-Hydroxycholesterol Drives the Spread of α-Synuclein Pathology in Parkinson's Disease.

Lijun DaiJiannan WangXingyu ZhangMingmin YanLingyan ZhouGuoxin ZhangLanxia MengLiam ChenXuebing CaoZhaohui ZhangGaohua WangZhentao Zhang

Published in: Movement disorders : official journal of the Movement Disorder Society (2023)

27-OHC promotes the aggregation and spread of α-Syn. Strategies aimed at inhibiting the CYP27A1-27-OHC axis may hold promise as a disease-modifying therapy to halt the progression of α-Syn pathology in PD. © 2023 International Parkinson and Movement Disorder Society.

Keyphrases

signaling pathway
big data
stem cells
machine learning
cell therapy