miR-322 treatment rescues cell apoptosis and neural tube defect formation through silencing NADPH oxidase 4.

Yu-Si LiuHui GuTian-Chu HuangXiao-Wei WeiWei MaDan LiuYi-Wen HeWen-Ting LuoJie-Ting HuangDuan ZhaoShan-Shan JiaFang Wang Ting ZhangYu-Zuo BaiWei-Lin WangZheng Wei Yuan

Published in: CNS neuroscience & therapeutics (2020)

miR-322/NOX4 plays a crucial role in apoptosis-induced NTD formation, which may provide a new understanding of the mechanism of embryonic NTDs and a basis for potential therapeutic target against NTDs.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
oxidative stress
high glucose
diabetic rats
cell death
mouse model
drug induced
pi k akt
endothelial cells
human health