Single-cell and spatial transcriptomics reveal POSTN + cancer-associated fibroblasts correlated with immune suppression and tumour progression in non-small cell lung cancer.

Chao ChenQiang GuoYang LiuQinghua HouMengying LiaoYanying GuoYupeng Zang Fei WangHuanyu LiuXinyu LuanYanling LiangZhuojue GuanYanling LiHaozhen LiuXuan DongXiuqing ZhangJixian LiuQumiao Xu

Published in: Clinical and translational medicine (2023)

CAFs associated with cancer progression and poor clinical outcomes and may provide new insights on the treatment of NSCLC.

Keyphrases

single cell
rna seq
small cell lung cancer
papillary thyroid
high throughput
squamous cell
genome wide
extracellular matrix
gene expression
childhood cancer
dna methylation
replacement therapy