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Is split-dose better than single-dose? Results of Turkish Stem Cell Coordination Center (TURKOK) donors in the era of rising biosimilar G-CSF.

İbrahim Ethem PınarVildan ÖzkocamanFahir ÖzkalemkaşHimmet DurgutBahar DakikiTuba ErsalVildan GürsoyCumali YalçınBedrettin OrhanÖmer CandarRıdvan Ali
Published in: Journal of clinical apheresis (2022)
Split-dose may be recommended for cases where the need for large numbers of CD34+ cells to be harvested is anticipated due to significant cell yield relative to recipient weight. However, sufficient hematopoietic stem cells can be collected with both posology. Tevagrastim is non-inferiority effective to Neupogen. Side effects during administration are both low-grade and temporary.
Keyphrases
  • stem cells
  • low grade
  • cell therapy
  • high grade
  • induced apoptosis
  • cell cycle arrest
  • single cell
  • bone marrow
  • body mass index
  • weight loss
  • physical activity
  • signaling pathway
  • mesenchymal stem cells