Neprilysin inhibition does not alter dynamic of proenkephalin-A 119-159 and pro-substance P in heart failure.

Henrike ArfstenGeorg GoliaschPhilipp E BartkoSuriya PrausmüllerGeorg SpinkaAnna ChoJohannes NovakJulia MascherbauerHelmuth HaslacherGuido StrunkMartin HülsmannNoemi Pavo

Published in: ESC heart failure (2021)

Although enkephalins and SP are known substrates of NEP, NEP inhibition by ARNi does not clearly affect the circulating precursors PENK and pro-SP in HFrEF.

Keyphrases

heart failure
anti inflammatory
left ventricular
cardiac resynchronization therapy