Tumor Mutation Burden and Differentially Mutated Genes Among Immune Phenotypes in Patients with Lung Adenocarcinoma.
Hao WangShanhao ChenDie MengChunyan WuJunjie ZhuMinlin JiangJing NingShengyu WuLijia WuJingjie LiBin ChenSha ZhaoWei LiJia YuQiyu FangCaicun ZhouWencheng ZhaoYayi HeCaicun ZhouPublished in: OncoTargets and therapy (2021)
Low TMB level could be the reason for the poor efficacy of ICBs in patients having EGFR mutation. And mutational frequencies of KRAS and BRCA2 were lower in EGFR-mutant patients. Furthermore, ALK, CDKN2A, MAP2K1, IDH2 and PTEN might involve in the formation of immune phenotypes.