Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patients.

Andreas GreinacherMark IbbersonBrian StevensonLeonore WiggerYoussef DaaliAnne NiknejadFrançois MachMylène DocquierIoannis XenariosThomas CuissetMarie-Christine AlessiJean-Luc Reny

Published in: Journal of thrombosis and haemostasis : JTH (2020)

This study emphasizes the role of CYP-related genes as major regulators of clopidogrel response, including the poorly investigated CYP2C8 and CYP2C18.

Keyphrases

acute coronary syndrome
end stage renal disease
percutaneous coronary intervention
ejection fraction
chronic kidney disease
newly diagnosed
antiplatelet therapy
prognostic factors
peritoneal dialysis
copy number
mass spectrometry
bioinformatics analysis