Pharmacologic Targeting of Mcl-1 Induces Mitochondrial Dysfunction and Apoptosis in B-Cell Lymphoma Cells in a TP53- and BAX-Dependent Manner.

Tingting LiuVi LamElana ThiemeDuanchen SunXiaoguang WangFei XuLili WangOlga V DanilovaZheng Xia Jeffrey W TynerStephen E KurtzAlexey V Danilov

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Selective targeting Mcl-1 is a promising therapeutic approach in lymphoid malignancies. TP53 apoptotic network and metabolic reprogramming underlie susceptibility to Mcl-1 inhibition.

Keyphrases

cell cycle arrest
induced apoptosis
cell death
endoplasmic reticulum stress
oxidative stress
cancer therapy
diffuse large b cell lymphoma
drug delivery
cell proliferation
anti inflammatory