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Pharmacologic Targeting of Mcl-1 Induces Mitochondrial Dysfunction and Apoptosis in B-Cell Lymphoma Cells in a TP53- and BAX-Dependent Manner.

Tingting LiuVi LamElana ThiemeDuanchen SunXiaoguang WangFei XuLili WangOlga V DanilovaZheng XiaJeffrey W TynerStephen E KurtzAlexey V Danilov
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Selective targeting Mcl-1 is a promising therapeutic approach in lymphoid malignancies. TP53 apoptotic network and metabolic reprogramming underlie susceptibility to Mcl-1 inhibition.
Keyphrases
  • cell cycle arrest
  • induced apoptosis
  • cell death
  • endoplasmic reticulum stress
  • oxidative stress
  • cancer therapy
  • diffuse large b cell lymphoma
  • drug delivery
  • cell proliferation
  • anti inflammatory