Pharmacologic Targeting of Mcl-1 Induces Mitochondrial Dysfunction and Apoptosis in B-Cell Lymphoma Cells in a TP53- and BAX-Dependent Manner.
Tingting LiuVi LamElana ThiemeDuanchen SunXiaoguang WangFei XuLili WangOlga V DanilovaZheng XiaJeffrey W TynerStephen E KurtzAlexey V DanilovPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Selective targeting Mcl-1 is a promising therapeutic approach in lymphoid malignancies. TP53 apoptotic network and metabolic reprogramming underlie susceptibility to Mcl-1 inhibition.