Paxillin binding to the PH domain of kindlin-3 in platelets is required to support integrin αIIbβ3 outside-in signaling.
Huong T T NguyenZhen XuXiaofeng ShiShuzhen LiuMarie L SchulteGilbert C WhiteYan-Qing MaPublished in: Journal of thrombosis and haemostasis : JTH (2021)
Taken together, these findings suggest that interaction between paxillin and the PH domain of kindlin-3 plays an important role in supporting integrin αIIbβ3 outside-in signaling in platelets, thus providing a novel antithrombotic target.