Sex and oestrous cycle are not mediators of S-ketamine's rapid-antidepressant behavioural effects in a genetic rat model of depression.

Shokouh ArjmandMarie Vadstrup PedersenNicole R SilvaAnne M LandauSâmia JocaGregers Wegener

Published in: The international journal of neuropsychopharmacology (2023)

We conclude that physiological oscillations of estrogen and progesterone levels neither amplify nor diminish the behavioural antidepressant-like effect of S-ketamine. In addition, fluctuations of ovarian sex hormones do not predispose female animals to exhibit enhanced or reduced depressive- and anxiety-like behaviours.

Keyphrases

major depressive disorder
estrogen receptor
bipolar disorder
sleep quality
pain management
depressive symptoms
working memory
genome wide
quantum dots
stress induced
copy number
chronic pain