Identification of Functional Genetic Variants Associated With Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay.

Kriti S ThapaAndy B ChenDongbing LaiXiaoling Xuei Leah Wetherill Jay A Tischfield Yunlong Liu Howard J Edenberg

Published in: Alcoholism, clinical and experimental research (2020)

The SNPs identified in the PASSPORT-seq assay are functional variants that might affect the risk for AD and related phenotypes. Our study provides insights into gene regulation in AD and demonstrates the value of PASSPORT-seq as a tool to screen genetic variants in GWAS loci for one potential mechanism of action.

Keyphrases

high throughput
genome wide
single cell
rna seq
copy number
dna methylation
gene expression
genome wide association study
alcohol consumption