Utility of Protein Microarrays for Detection of Classified and Novel Antibodies in Autoimmune Neurologic Disease.

Andrew McKeonConnie Lesnick Nisa Vorasoot Monica W Buckley Surendra DasariEoin P FlanaganMichael Gilligan Reghann Lafrance-CoreyRamona MiskeSean J PittockMadeleine ScharfBinxia YangAnastasia ZekeridouDivyanshu DubeyJohn Mills

Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)

Individualized autoimmune neurologic diagnoses may be accelerated using protein arrays. They are optimal for detection of intracellular antigen-reactive antibodies, though certain cell surface-directed antibodies (neurexin-3α and SEZ6L2) may also be detected.

Keyphrases

cell surface
multiple sclerosis
loop mediated isothermal amplification
protein protein
real time pcr
label free
binding protein
drug induced
reactive oxygen species