Exploratory Multisite Magnetic Resonance Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children.
Leon Y CaiC TanaseA W AndersonN J PatelC A LeeR S JonesL M LeStourgeonA MahonI TakiJ JuveraSumit PruthiK GwalA OzturkHakmook KangArleta RewersM J RewersGuy Todd AlonsoN GlaserS GhettiSarah S JaserBennett A LandmanLori C JordanPublished in: AJNR. American journal of neuroradiology (2023)
Our pilot study suggests that MRSI differentiates GM and WM by NAA/Cr in this population, disease complications may lead to neuroaxonal loss in WM in children, and deeper investigation is warranted to further untangle how diabetic ketoacidosis and chronic hyperglycemia affect brain health and cognition in type 1 diabetes.
Keyphrases
- white matter
- type diabetes
- magnetic resonance
- young adults
- multiple sclerosis
- public health
- healthcare
- risk factors
- high resolution
- cardiovascular disease
- molecular docking
- insulin resistance
- magnetic resonance imaging
- mild cognitive impairment
- climate change
- resting state
- metabolic syndrome
- functional connectivity
- oxidative stress
- social media
- glycemic control
- cerebral ischemia