Creatine Kinase is Decreased in Childhood Asthma.

Stefano GuerraJulie G LedfordErik MelénIris LaviAnne-Elie CarsinDebra A SternJing ZhaiMarta VidalMariona BustamanteKenneth J AddisonRenata G VallecilloDean BillheimerGerard H KoppelmanJudith M Garcia-AymerichNathanaël LemonnierMontserrat FitóCarlota DobañoSimon Kebede MeridInger KullRosemary R C McEachanJohn WrightLeda ChatziManolis KogevinasDaniela PortaSilvia NarduzziFerran BallesterAna EspluguesCarlos ZabaletaAmaia IrizarJordi SunyerMarilyn HalonenJean BousquetFernando D MartinezJosep M Anto

Published in: American journal of respiratory and critical care medicine (2022)

Circulating levels and gene expression of CK are inversely associated with childhood asthma. Mouse models support a possible direct involvement of CK in asthma protection via inhibition of AHR and reduction of airway mucin.

Keyphrases

chronic obstructive pulmonary disease
lung function
gene expression
protein kinase
allergic rhinitis
mouse model
dna methylation
early life
cystic fibrosis
air pollution
young adults