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Prolonged exposure to simulated microgravity promotes stemness impairing morphological, metabolic and migratory profile of pancreatic cancer cells: a comprehensive proteomic, lipidomic and transcriptomic analysis.

Maria Angela MasiniValentina BonettoMarcello ManfrediAnna PastoElettra BarberisSara TimoVirginia Vita VanellaElisa RobottiFrancesca MasettoFrancesca AndreoliAlessandra FioreSara TavellaAntonio SicaMassimo DonadelliEmilio Marengo
Published in: Cellular and molecular life sciences : CMLS (2022)
SMG revolutionizes tumor cell behavior and metabolism leading to the acquisition of an aggressive and metastatic stem cell-like phenotype. These results dissect the time-dependent cellular alterations induced by SMG and pave the base for altered gravity conditions as new anti-cancer technology.
Keyphrases
  • stem cells
  • cell therapy
  • single cell
  • squamous cell carcinoma
  • small cell lung cancer
  • epithelial mesenchymal transition