Construction of Phlorotannin-Based Nanoparticles for Alleviating Acute Liver Injury.
Fengxian LuoBeiwei ZhuDi WuYu XuTao ChenYanfei LiJiang-Ning HuPublished in: ACS applied materials & interfaces (2023)
Acute liver injury (ALI) is a severe health condition with limited treatment options. Phlorotannin (PT), a natural compound extracted from seaweeds, has shown potential in improving liver function. However, its poor stability and bioavailability have limited its applications in vivo. In this study, we developed PT-based nanoparticles (NPs) through a Mannich reaction with glycine, which exhibited good biocompatibility and prolonged circulation time in vivo. Our results revealed that the PT NPs possess strong free radical scavenging ability, effectively reducing reactive oxygen species (ROS) and alleviating oxidative stress and proinflammatory responses in the H 2 O 2 -induced oxidative damage model of HepG2 cells. Furthermore, the PT NPs effectively attenuated oxidative stress and inflammation in the liver tissue of carbon tetrachloride (CCl 4 )-induced liver injury mice by regulating the Nrf2/HO-1 signaling pathway. In summary, our results suggested that the PT NPs could serve as a promising nano-therapeutic strategy for alleviating ALI.
Keyphrases
- liver injury
- drug induced
- oxidative stress
- reactive oxygen species
- diabetic rats
- dna damage
- signaling pathway
- induced apoptosis
- healthcare
- ischemia reperfusion injury
- public health
- pi k akt
- mental health
- epithelial mesenchymal transition
- type diabetes
- metabolic syndrome
- adipose tissue
- heat shock
- walled carbon nanotubes
- skeletal muscle
- heat shock protein