Dietary Supplementation of Methyl Donor l-Methionine Alters Epigenetic Modification in Type 2 Diabetes.

Umashanker NavikVaibhav G ShethShaheen Wasil KabeerKulbhushan Tikoo

Published in: Molecular nutrition & food research (2019)

The first evidence that dietary supplementation of l-Met prevents diabetes-induced epigenetic alterations and regulating methionine levels can be therapeutically exploited for the treatment of metabolic diseases is provided.

Keyphrases

type diabetes
dna methylation
glycemic control
gene expression
cardiovascular disease
high glucose
diabetic rats
amino acid
insulin resistance
drug induced
mouse model
adipose tissue
combination therapy
metabolic syndrome
skeletal muscle
endothelial cells
oxidative stress