Efficacy and Safety of Low-Dose Prasugrel Versus Clopidogrel in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: a Systematic Review and Meta-analysis.
Yuttana WongsalapSupakorn UngsriwongWanalee KumtepSurasak SaokaewVichai SenthongKirati KengklaPublished in: Cardiovascular drugs and therapy (2021)
We found that low-dose prasugrel was not associated with changes in MACE or major bleeding compared with clopidogrel in RCTs. However, analysis of data from observational studies revealed that low-dose prasugrel was associated with an increased risk of major bleeding compared with clopidogrel.
Keyphrases
- percutaneous coronary intervention
- low dose
- acute coronary syndrome
- st segment elevation myocardial infarction
- antiplatelet therapy
- atrial fibrillation
- st elevation myocardial infarction
- acute myocardial infarction
- coronary artery disease
- coronary artery bypass grafting
- high dose
- coronary artery bypass
- electronic health record
- heart failure
- single cell
- big data
- left ventricular
- artificial intelligence