A statistical and biological response to an informatics appraisal of healthy aging gene signatures.

James A TimmonsIain J GallagherSanjana SoodBethan PhillipsHannah CrosslandRobert HowardWilliam E KrausPhilip J Atherton

Published in: Genome biology (2019)

Jacob and Speed did not identify even a single example of a '150-gene-set' that was statistically significant at classifying Alzheimer's disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below.

Keyphrases

genome wide
copy number
genome wide identification
cognitive decline
gene expression
machine learning
mild cognitive impairment
artificial intelligence