New Cyclopiane Diterpenes and Polyketide Derivatives from Marine Sediment-Derived Fungus Penicillium antarcticum KMM 4670 and Their Biological Activities.
Anton Nikolaevich YurchenkoOlesya I ZhuravlevaOlga O KhmelGalina K OleynikovaAlexandr S AntonovNatalya N KirichukViktoria E ChausovaAnatoly I KalinovskyDmitry V BerdyshevNatalya Y KimRoman Sergeevich PopovEkaterina A ChingizovaArtur R ChingizovMarina P IsaevaEkaterina A YurchenkoPublished in: Marine drugs (2023)
Two new cyclopiane diterpenes and a new cladosporin precursor, together with four known related compounds, were isolated from the marine sediment-derived fungus Penicillium antarcticum KMM 4670, which was re-identified based on phylogenetic inference from ITS, BenA , CaM , and RPB2 gene regions. The absolute stereostructures of the isolated cyclopianes were determined using modified Mosher's method and quantum chemical calculations of the ECD spectra. The isolation from the natural source of two biosynthetic precursors of cladosporin from a natural source has been reported for the first time. The antimicrobial activities of the isolated compounds against Staphylococcus aureus , Escherichia coli , and Candida albicans as well as the inhibition of staphylococcal sortase A activity were investigated. Moreover, the cytotoxicity of the compounds to mammalian cardiomyocytes H9c2 was studied. As a result, new cyclopiane diterpene 13- epi -conidiogenone F was found to be a sortase A inhibitor and a promising anti-staphylococcal agent.
Keyphrases
- staphylococcus aureus
- biofilm formation
- candida albicans
- escherichia coli
- heavy metals
- methicillin resistant staphylococcus aureus
- molecular dynamics
- density functional theory
- polycyclic aromatic hydrocarbons
- single cell
- molecular dynamics simulations
- risk assessment
- pseudomonas aeruginosa
- high resolution
- multidrug resistant
- monte carlo
- mass spectrometry
- transcription factor
- high glucose
- energy transfer
- structure activity relationship