Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories.
Connor BargarChiara Maria Giulia De LucaGrazia DevigiliAntonio Emanuele EliaRoberto CiliaSara Maria PortaleoneWen WangIrene TramacereEdoardo BistaffaFederico Angelo CazzanigaGiovanni FelisatiGiuseppe LegnameAlessio Di FonzoRong XuSteven Alexander GunzlerGiorgio GiacconeRoberto EleopraShu Guang ChenFabio ModaPublished in: Molecular neurodegeneration (2021)
may serve as a novel biomarker for accurate clinical diagnoses of PD, MSA-P, and MSA-C. Moreover, αSyn_RT-QuIC represents a reliable assay that can distinguish patients with MSA-P from those with MSA-C, and may lead to significant advancements in patients stratification and selection for emerging pharmacological treatments and clinical trials.