Cobalt-catalyzed, directed arylation of C-H bonds in N -aryl pyrazoles.

Tung Thanh NguyenLam V LeHai H PhamDung H NguyenNam Thanh Son PhanHa V LeAnh N Q Phan

Published in: RSC advances (2021)

We report a method for directed ortho -arylation of N -aryl pyrazoles with arylboronic acids. Reactions proceeded in the presence of a Co(hfacac) 2 catalyst, CeSO 4 oxidant, and HFIP solvent. Functionalities such as nitro, ester, bromo, and ketone groups were compatible with the reaction conditions. Using heterocycles including thiophene and carbazole was also feasible.

Keyphrases

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