Childhood adverse life events and skeletal muscle mitochondrial function.
Kate A DuchownyTheresa MauL Grisell Diaz-RamierzLi-Yung LuiDavid J MarcinekFrederico G S ToledoPeggy M CawthonRussell T HepplePhilip A KramerAnne B NewmanStephen B KritchevskySteven R CummingsPaul M CoenAnthony J A MolinaPublished in: medRxiv : the preprint server for health sciences (2023)
Social stress experienced in childhood is associated with adverse health later in life. Mitochondrial function has been implicated as a mechanism for how stressful life events "get under the skin" to influence physical wellbeing. Using data from the Study of Muscle, Mobility and Aging (n=879, 59% women), linear models examined whether adverse childhood events (i.e., physical abuse) were associated with two measures of skeletal muscle mitochondrial energetics in older adults: (1) maximal adenosine triphosphate production (ATP max ) and (2) maximal state 3 respiration (Max OXPHOS). Forty-five percent of the sample reported experiencing 1+ adverse childhood event. After adjustment, each additional event was associated with -0.07 SD (95% CI= - 0.12, -0.01) lower ATP max . No association was observed with Max OXPHOS. Adverse childhood events are associated with lower ATP production in later life. Findings indicate that mitochondrial function may be a mechanism in understanding how early social stress influences health in later life.
Keyphrases
- skeletal muscle
- mental health
- healthcare
- physical activity
- early life
- public health
- childhood cancer
- emergency department
- oxidative stress
- heart rate
- adverse drug
- pregnant women
- machine learning
- young adults
- metabolic syndrome
- polycystic ovary syndrome
- blood pressure
- health information
- deep learning
- stress induced
- artificial intelligence
- data analysis
- human health
- wound healing