Exploring the Effect of Jiawei Buguzhi Pills on TGF-β-Smad Pathway in Postmenopausal Osteoporosis Based on Integrated Pharmacological Strategy.
Xiao YuanYonghe WuKailin YangHuiping LiuGuomin ZhangPublished in: Evidence-based complementary and alternative medicine : eCAM (2021)
JWBGZP may be involved in PI3K-Akt, HIF-1, estrogen, prolactin, and other signaling pathways and regulate MAPK1, AKT1, PIK3CA, JAK2, and other gene targets, regulate bone metabolism, and thereby treat PMO.
Keyphrases
- pi k akt
- signaling pathway
- bone mineral density
- epithelial mesenchymal transition
- transforming growth factor
- postmenopausal women
- cell proliferation
- cell cycle arrest
- body composition
- induced apoptosis
- genome wide
- copy number
- estrogen receptor
- endothelial cells
- genome wide identification
- dna methylation
- gene expression
- protein kinase
- oxidative stress
- cell death