Identification of Three Potential Prognostic Genes in Platinum-Resistant Ovarian Cancer via Integrated Bioinformatics Analysis.

Xue ZhangXuan WeiGaigai BaiXueyao HuangShunxue HuHongluan MaoPei-Shu Liu

Published in: Cancer management and research (2021)

ATP1A2, CASQ2 and RYR2 were highly expressed in platinum-resistant ovarian cancer. ATP1A2 and CASQ2 were related to the prognosis of platinum-resistant ovarian cancer patients. These genes might act on KARS and mTORC1 pathways and participate in metabolic reprogramming and regulation of calcium homeostasis in platinum-resistant cells.

Keyphrases

bioinformatics analysis
genome wide
induced apoptosis
gene expression
risk assessment
transcription factor
genome wide identification
cell proliferation
human health
genome wide analysis