Inhibiting protein phosphatase 2A increases the antitumor effect of protein arginine methyltransferase 5 inhibition in models of glioblastoma.
Yoshihiro OtaniHannah P SurGuruprasad RachaiahSriya NamagiriAshis ChowdhuryCole T LewisToshihiko ShimizuArunakumar GangaplaraXiang WangAmélie VézinaDragan MaricSadhana JacksonYuanqing YanZhuang ZhengpingAbhik Ray-ChaudhurySachin KumarLeomar Y BallesterPrashant ChitiboinaJi Young YooJohn HeissBalveen KaurYeshavanth Kumar Banasavadi-SiddegowdaPublished in: Neuro-oncology (2021)
Overall, combined PRMT5 and PP2A inhibition had significantly greater antitumor effects than PRMT5 inhibition alone.