Inhibition of circulating dipeptidyl-peptidase 3 by procizumab in experimental septic shock reduces catecholamine exposure and myocardial injury.
Bruno GarciaBenoit Ter SchiphorstKarine SantosFuhong SuLaurence DewachterFrancisco Vasques-NóvoaEstela Rocha-OliveiraRoberto Roncon-AlbuquerqueTheo UbaOliver HartmannAdrien PicodFeriel AzibaniJacques CallebertSerge GoldmanFilippo AnnoniRaphaël FavoryJean-Louis VincentJacques CreteurFabio Silvio TacconeAlexandre MebazaaAntoine HerpainPublished in: Intensive care medicine experimental (2024)
In an experimental model of septic shock, PCZ administration was associated with reduced fluid and catecholamine requirements, less myocardial injury and cardiovascular inflammation, along with preserved angiotensin II signaling.