Adiponectin regulates bone mass in AIS osteopenia via RANKL/OPG and IL6 pathway.

Hong-Qi ZhangLong-Jie WangShao-Hua LiuJiong LiLi-Ge XiaoGuan-Teng Yang

Published in: Journal of translational medicine (2019)

Our results indicated that high circulating adiponectin levels may result from gene variations in AIS osteopenia. Adiponectin has a negative effect on bone metabolism, and this negative effect might be mediated by the ADR1-RANKL/OPG and ADR1-IL6 pathways.

Keyphrases

bone loss
metabolic syndrome
insulin resistance
bone mineral density
type diabetes
postmenopausal women
gene expression
skeletal muscle
inflammatory response
transcription factor
electronic health record