Efficacy and safety of ciclosporin versus methotrexate in the treatment of severe atopic dermatitis in children and young people (TREAT): a multicentre, parallel group, assessor-blinded clinical trial.
Carsten FlohrAnna Rosala-HallasAshley P JonesPaula BeattieSusannah BaronFiona BrowneSara J BrownJoanna E GachDanielle GreenblattRoss HearnEva HilgerBen EsdaileMichael J CorkEmma HowardMarie-Louise LovgrenSuzannah AugustFarhiya AshoorPaula R WilliamsonTess McPhersonDonal O'KaneJane C RavenscroftLindsay ShawManish D SinhaCatherine SpowartLeonie S TaamsBjorn R ThomasMandy WanTracey H SachAlan D IrvinePublished in: The British journal of dermatology (2023)
Both CyA and MTX proved effective in CYP with severe AD over 36 weeks. CyA showed a more rapid response to treatment, while MTX induced more sustained disease control after discontinuation.