Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis.
Brienne A McKenzieJason P FernandesMatthew A L DoanLaura M SchmittWilliam G BrantonChristopher PowerPublished in: Journal of neuroinflammation (2020)
Activation of executioner caspases-3/7, widely considered key mediators of apoptosis, contributed to GSDMD-associated microglial pyroptosis under neuroinflammatory conditions. Collectively, these observations highlight the convergence of different cell death pathways during neuroinflammation and offer new therapeutic opportunities in neuroinflammatory disease.