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Recombinant proteins of Plasmodium malariae merozoite surface protein 1 (PmMSP1): Testing immunogenicity in the BALB/c model and potential use as diagnostic tool.

Yelina B ElizardezWesley L FotoranAndrés J Galisteo JuniorIzilda CuradoNorival Kesper JuniorEliana F MonteiroIrineu Romero NetoGerhard WunderlichKarin Kirchgatter
Published in: PloS one (2019)
Recombinant PmMSP1 proteins are very useful diagnostic markers of P. malariae in epidemiological studies or in the differential diagnosis of malaria caused by this species. Immunization with recombinant PmMSP1 proteins resulted in a significant humoral immune response, which may turn them potential component candidates for a vaccine against P. malariae.
Keyphrases
  • immune response
  • plasmodium falciparum
  • cell free
  • dendritic cells
  • small molecule
  • sensitive detection
  • fluorescent probe
  • inflammatory response
  • quantum dots
  • case control