Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumours display divergent genomic and transcriptomic profiles.

Michele SimboloSamantha BersaniCaterina VicentiniSergio V TaorminaChiara CiaparroneFabio BaganteBorislav RusevGiovanni CentonzeMarina MontresorMatteo BrunelliSerena PedronAndrea MafficiniGaetano PaolinoPaola MattioloSimone ConciMassimo MilioneAlfredo GuglielmiAndrea RuzzenenteAldo ScarpaClaudio Luchini

Published in: Expert opinion on therapeutic targets (2021)

This study provides new insights into the molecular landscape and the actionable alterations of ECC. Our findings represent a step toward improved ECC molecular taxonomy and future therapeutic strategies for precision oncology.

Keyphrases

single cell
palliative care
minimally invasive
current status
single molecule
copy number
rna seq
genome wide