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Low-grade glioma: A rare second tumor in retinoblastoma survivors.

Nagma DalviRuth A KleinermanSidnei EpelmanDavid H AbramsonIra J Dunkel
Published in: Pediatric blood & cancer (2020)
Retinoblastoma survivors with a germline RB1 mutation are at elevated risk for secondary (nonocular) malignancy, but their risk for low-grade glioma (LGG) is unknown. We performed a retrospective review of the Memorial Sloan Kettering Cancer Center and the NCI databases that revealed that three of the 837 5-year survivors of hereditary retinoblastoma were diagnosed with an LGG and a fourth patient (but unilateral and without a germline mutation) was identified at another center. Retinoblastoma survivors may be at increased risk for LGG.
Keyphrases
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