Posttranslational modifications of the DUX4 protein impact toxic function.

Renatta N KnoxJocelyn O EidahlLindsay WallaceSarah ChouduryAfrooz RashnonejadKatelyn DamanMatthew GuggenbillerNizar Y SaadMichael E HooverLiwen ZhangOwen E BransonCharles P EmersonMichael A FreitasScott Q Harper

Published in: Annals of neurology (2023)

These results support that DUX4 is regulated by PTMs and set a foundation for developing FSHD drug screens based mechanistically on DUX4 PTMs and modifying enzymes. This article is protected by copyright. All rights reserved.

Keyphrases

high throughput
genome wide
adverse drug
emergency department