The Dual Angiogenesis Effects via Nrf2/HO-1 Signaling Pathway of Melatonin Nanocomposite Scaffold on Promoting Diabetic Bone Defect Repair.
Tingting ChenZimei WuQiaodan HouYixin MeiKunkun YangJing XuLin WangPublished in: International journal of nanomedicine (2024)
This study demonstrated the research prospective and clinical implications of the MT nanocomposite scaffold as a novel bone graft for treating bone defect and enhancing bone fusion in diabetic individuals.
Keyphrases
- bone mineral density
- signaling pathway
- soft tissue
- bone loss
- type diabetes
- bone regeneration
- wound healing
- postmenopausal women
- oxidative stress
- pi k akt
- reduced graphene oxide
- endothelial cells
- body composition
- vascular endothelial growth factor
- cell proliferation
- tissue engineering
- solid phase extraction
- simultaneous determination
- liquid chromatography
- tandem mass spectrometry