Brain and Placental Pathology in Fetal COL4A1 Related Disease.
Patrick ShannonCourtney HumTony ParksG M SchauerDavid ChitayatKaren ChongShiri ShinarSusan BlaserGaea MooreTim Van MieghemPublished in: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society (2021)
These cases confirm that small vessel disease is important in producing intracranial pathology in COL4A1mutation. We report an arteriopathy distinct from microvascular thrombosis and demonstrate that placental pathology is common in fetal COL4A1 related disease. This tentatively suggests that placental pathology may contribute to CNS abnormalities by affecting circulatory sufficiency.