A conventional immune regulator MAVS blocks hepatic steatosis via maintaining mitochondrial homeostasis.

Jiajun FuFengjiao HuTengfei MaWen-Jie ZhaoHan TianYan ZhangMan-Li HuJunjie ZhouYanfang ZhangChongshu JianYan-Xiao JiXiao-Jing ZhangJingwei JiangZhi-Gang SheXu ChengPeng ZhangLan BaiJuan YangHongliang Li

Published in: Hepatology (Baltimore, Md.) (2021)

In hepatocytes, MAVS plays an important role in protecting against NAFLD by helping to regulate healthy mitochondrial function. These findings provide new insights regarding the metabolic importance of conventional immune regulators and support the possibility that targeting MAVS may represent a new avenue for treating NAFLD.

Keyphrases

transcription factor
oxidative stress
liver injury
drug delivery
drug induced