Effective chemotherapy of heterogeneous and drug-resistant early colon cancers by intermittent dose schedules: a computer simulation study.
David E AxelrodSudeepti VedulaJames ObaniyiPublished in: Cancer chemotherapy and pharmacology (2017)
An intermittent dose, at the maximum that allows colon crypt maintenance, can be effective in eliminating a heterogeneous mixture of mutant subclones before they fill the crypt and form an adenoma.