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Timeline of Rapid Eye Movement Sleep Behavior Disorder in Overt Alpha-Synucleinopathies.

Cole D StangAidan F MullanMania HajebEmanuele CamerucciPierpaolo TurcanoPeter MartinMichelle M MielkeKeith Anthony JosephsJames H BowerErik K St LouisBradley F BoeveRodolfo Savica
Published in: Annals of neurology (2020)
Our cohort had RBD incidence of 3.4%. Overall RBD increased to 23.8% after 15 years, with an overall incidence of 2.5 cases per 100 person-years. With 53 times greater lifetime incidence in alpha-synucleinopathy patients than in controls, RBD was more likely to develop in dementia with Lewy bodies than in Parkinson disease or Parkinson disease dementia, and in men than in women, but did not increase mortality risk within our cohort. ANN NEUROL 2021;89:293-303.
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