Urine biomarkers of chronic kidney damage and renal functional decline in childhood-onset systemic lupus erythematosus.
Hermine I BrunnerGaurav GulatiMarisa S Klein-GitelmanKelly A Rouster-StevensLori TuckerStacey P ArdoinKaren B OnelRylie MainvilleJessica TurnierPinar Ozge Avar AydinDavid WitteBin HuangMichael R BennettPrasad DevarajanPublished in: Pediatric nephrology (Berlin, Germany) (2018)
• Levels of osteopontin and adiponectin measured at the time of kidney biopsy are good predictors of histological damage with lupus nephritis. • Only about 20% of children with substantial kidney damage from lupus nephritis will have an abnormally low urine creatinine clearance. • Continuously high levels of biomarkers reflecting lupus nephritis activity are risk factors of declining renal function.