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Urine biomarkers of chronic kidney damage and renal functional decline in childhood-onset systemic lupus erythematosus.

Hermine I BrunnerGaurav GulatiMarisa S Klein-GitelmanKelly A Rouster-StevensLori TuckerStacey P ArdoinKaren B OnelRylie MainvilleJessica TurnierPinar Ozge Avar AydinDavid WitteBin HuangMichael R BennettPrasad Devarajan
Published in: Pediatric nephrology (Berlin, Germany) (2018)
• Levels of osteopontin and adiponectin measured at the time of kidney biopsy are good predictors of histological damage with lupus nephritis. • Only about 20% of children with substantial kidney damage from lupus nephritis will have an abnormally low urine creatinine clearance. • Continuously high levels of biomarkers reflecting lupus nephritis activity are risk factors of declining renal function.
Keyphrases
  • systemic lupus erythematosus
  • risk factors
  • oxidative stress
  • metabolic syndrome
  • young adults
  • disease activity
  • insulin resistance
  • adipose tissue
  • drug induced
  • childhood cancer